1Department of Anesthesiology, Chung Shan Medical University Hospital, Taichung, Taiwan
Musculoskeletal diseases are common causes of chronic pain, they severely impair the patients’ quality of life. An aging population could lead to enormously large number of patients diagnosed with musculoskeletal diseases. Management of musculoskeletal diseases can be surgical or non-surgical. Surgical modalities include tissue repair, a joint replacement surgery, and so forth. With the rising cost surgical procedures, the financial burden of health care may be growing, and the quality of life among general populations will be affected eventually.
Dextrose Prolotherapy is another cost-effective treatment option. Avoiding surgical intervention and with lower cost, some cases reported clinically significant improvement with dextrose Prolotherapy. However, the actual mechanism of
dextrose Prolotherapy is yet not totally clear. Most investigators proposed that by injection at least 10% dextrose into tendon or ligament insertions, inflammatory process will be induced, proliferation of various cells at injection site will be noted and finally healing of the injured structures will take place.Some other investigators found that dextrose injections below a 10% solution directly stimulate proliferation of cells and tissue without causing a histological inflammatory reaction. Both mechanisms mentioned above could reduce the pain severity and improve the daily activity and quality.
This review focus on dextrose Prolotherapy on some common painful musculoskeletal diseases, the research evidence, and its possible explanations.
Prolotherapy; Glucose;Musculoskeletal diseases; Chronic pain
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