Back ground and purpose: Few studies have investigated the presence of comorbidity and the outcome of idiopathic adhesive capsulitis, and they usually involved a small number of patients. This study aims to investigate the influence of comorbidity on the duration of non-steroidal anti-inflammatory drug (NSAID) therapy in idiopathic adhesive capsulitis patients using a population-based database.Methods: A population-based cross-sectional study was conducted to examine if comorbidity associated with long-term (＞28 days) NSAID therapy in patients with idiopathic adhesive capsulitis. Records of 439 adhesive capsulitis patients with long-term NSAID therapy and 7,569 adhesive capsulitis patients with? 28 days NSATD therapy were collected. Conditional logistic regression analyses were applied to explore the differences between the two groups in terms of age, gender, and selected systemic comorbid diseases including diabetes mellitus (DM), hyperthyroidism, hypothyroidism, ischemic heart disease, and hyperlipidemia.Result: The OR of hyperlipidemia with long-term N SAID use in patients with adhesive capsulitis was 1.3 14 (95 % CL 1.015-1.700; p=0.038. The OR of age with long-term NSAID use in patients with adhesive capsulitis was 1.02 (95 % CI, 1.011-1.029; p＜0.001). There were no significant differences between the two groups regarding DM, hyperthyroidism, hypothyroidism, ischemic heart disease, and patient gender.Conclusion: This study shows an association between hyperlipidemia and long-term NSAID dmg therapy in idiopathic adhesive capsulitis patients. Cardiovascular risk associates with hyperlipidemia and NSAID medication use. Physicians should, therefore, carefully evaluate the need for NSAID medication treatment in adhesive capulitis patients with concomitant hyperlipidemia. Further investigation is needed to confirm the relationship found in the present study.