Taxanes and Neuropathic Pain in Taiwan Breast Cancer Patients
蔡欣恬(Hsin-Tien Tsai);馮文侃(Wen-Kan Feng);施盈逸(Ying-Yih Shih);何天輝(Thien-Fiew Ho);李銘家(Min-Jia Li);黃其晟(Chi-Cheng Huang)
Taxanes, docetaxel and paclitaxel are anticancer agents widely used for breast cancer treatment. The toxicity and neuropathic pain of paclitaxel are well discussed in the literatures; less research focus on docetaxel.Material and Method: We enrolled patients newly diagnosed breast cancer from 1 million insured sampling of National Health Insurance claim database from January 1998 to December 2006. Patients are divided into four groups: docetaxel (d), paclitaxel (p), both (d+p), none (n). Diagnosis of neuropathic pain and the usage of analgesics and hypnotics were recorded and analyzed.Results: Both groups were found to have significant incidence of neuropathic pain. Docetaxel group demonstrated significant usage of analgesics and hypnotics.Conclusion: The toxicity of docetaxel may be underestimated. Remind the occurrence of neuropathic pain while using the protocol of combination of two taxanes.