Infantile colic is one of the most frequent chief complain by parents in the pediatrics clinics. It was described as paroxysmal, high-pitched and inconsolable crying that lasted for hours, usually during late evening, and affecting newborn younger than 3 months of age. This circumstance not only caused pain and discomfort to the child, but also induced distress emotions to all family members. Many theories have been proposed regarding the etiologies of infantile colic. Some of the commonly discussed causative factors include maternal-child psychosocial conflict, gut hormones impairment, intestinal motility dysregulation, gastroesophageal reflux, carbohydrate malabsorption, protein allergy, and altered intestinal flora. Many suggestions have been proposed to cope with the disease but there is no consensus yet. These include behavioral interventions, naturopathic therapy, pharmacological treatment as well as dietary management. Recent studies have shown that both protein hydrolysates formula and low lactose formula can reduce the incident rate and crying time. Thus, the emergence of new combination of partial hydrolyzed proteins and low lactose formula might be a promising solution for infantile colic. On the other hand, some evidences also revealed that infant with colic might benefit from supplement of certain probiotics. However, larger studies are necessary before evidence-based recommendations can be made. In conclusions, the efficacy of therapy depends on the etiology which caused infantile colic. Until today, no single intervention has been proven to be perfectly effective in all cases. While dealing with this problem, safety issue is also one of the main concerns to both parents and physician.