Application of liposome on anesthesia and analgesia: a review
林冠儒(Kuan-Ju Lin);王祈斐(Chi-Fei Wang);劉彥青(Yen-Chin Liu);鐘士傑(Shih-Chieh Chung)
Limited therapeutic duration is an important clinic concern for local anesthetic agents. Prolonged duration of local anesthetics is thus actively investigated and liposome is one of the most promising delivery system to extend the therapeutic duration. Liposome loaded with bupivacaine (liposomal bupivacaine) had been approved by Food and Drug Administration in United States using in local surgical wound infiltration and transversus abdominis plane blocks. There are several clinical trials examining the safety and efficacy of liposomal bupivacaine in thoracic, orthopedic, abdominal surgeries and peripheral nerve block. Decrease in post-operative pain, admission cost, length of stay and post-operative consumption of opioid were generally revealed but the efficacy in nerve block was still under debate. Novel application of liposome including encapsulated site-l sodium channel blocker and repeatable release controlled by near-infrared light is also an emerging method conducted in animal models. In this review, we presented the recent clinical results and the possible future for liposome.